Regulation of daptomycin biosynthesis in Streptomyces roseosporus : new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production

Abstract excerpt

-nitrosoguanidine (MNNG) mutagenesis, are available for comparitive studies. DNA sequence analysis of the daptomycin biosynthetic gene clusters (BGCs) from these strains indicates that the high producer has two mutations in a large promoter region that drives the transcription of a giant multicistronic mRNA that includes all nine genes involved in daptomycin biosynthesis. The locations of translational start and...

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