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Article

Improvement of daptomycin production in Streptomyces roseosporus through the acquisition of pleuromutilin resistance.

BioMed research international - 1 Jan 2013

Li Linli, Ma Tingmei, Liu Qing, Huang Yuqi, Hu Changhua, Liao Guojian

Abstract excerpt

Daptomycin, a cyclic lipopeptide antibiotic produced by Streptomyces roseosporus, displays potent activity against a variety of gram-positive pathogens. There is a demand for generating high-producing strains for industrial production of this valuable antibiotic. Ribosome engineering is a powerful strategy to enhance the yield of secondary metabolites. In this study, the effect of a diterpenoid antibiotic...

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Identifiers

PMID: 24106707
DOI: 10.1155/2013/479742
PMCID: PMC3782809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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