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Article

Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease.

NeuroImage - 1 Feb 2009

Filippini Nicola, Rao Anil, Wetten Sally, Gibson Rachel A, Borrie Michael, Guzman Danilo, Kertesz Andrew, Loy-English Inge, Williams Julie, Nichols Thomas, Whitcher Brandon, Matthews Paul M

Abstract excerpt

APOE epsilon4 is the best-established genetic risk factor for sporadic Alzheimer's disease (AD). However, while homozygotes show greater disease susceptibility and earlier age of onset than heterozygotes, they may not show faster rates of clinical progression. We hypothesize that there are differential APOE epsilon4 allele-load dependent influences on neuropathology across the brain. Our aim was to define the...

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Source

Identifiers

PMID: 19013250
DOI: 10.1016/j.neuroimage.2008.10.003

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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