Article
Hippocampal and frontolimbic function as intermediate phenotype for psychosis: evidence from healthy relatives and a common risk variant in CACNA1C.
Biological psychiatry - 15 Sept 2014
Erk Susanne, Meyer-Lindenberg Andreas, Schmierer Phöbe, Mohnke Sebastian, Grimm Oliver, Garbusow Maria, Haddad Leila, Poehland Lydia, Mühleisen Thomas W, Witt Stephanie H, Tost Heike, Kirsch Peter, Romanczuk-Seiferth Nina, Schott Björn H, Cichon Sven, Nöthen Markus M, Rietschel Marcella, Heinz Andreas, Walter Henrik
Abstract excerpt
BACKGROUND: Variation in CACNA1C has consistently been associated with psychiatric disease in genome-wide association studies. We have previously shown that healthy carriers of the CACNA1C rs1006737 risk variant exhibit hippocampal and perigenual anterior cingulate (pgACC) dysfunction during episodic memory recall. To test whether this brain systems-level abnormality is a potential intermediate phenotype for...
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