Article
Intermediate phenotypes in psychiatric disorders.
Current opinion in genetics & development - 1 Jun 2011
Rasetti Roberta, Weinberger Daniel R
Abstract excerpt
The small effect size of most individual risk factors for psychiatric disorders likely reflects biological heterogeneity and diagnostic imprecision, which has encouraged genetic studies of intermediate biological phenotypes that are closer to the molecular effects of risk genes than are the clinical symptoms. Neuroimaging-based intermediate phenotypes have emerged as particularly promising because they map risk...
Topics
- Brain
- Brain Mapping
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Memory, Short-Term
- Mental Disorders
- Phenotype
- Schizophrenia