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Article

Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding.

Translational psychiatry - 18 Mar 2014

Schott B H, Assmann A, Schmierer P, Soch J, Erk S, Garbusow M, Mohnke S, Pöhland L, Romanczuk-Seiferth N, Barman A, Wüstenberg T, Haddad L, Grimm O, Witt S, Richter S, Klein M, Schütze H, Mühleisen T W, Cichon S, Rietschel M, Noethen M M, Tost H, Gundelfinger E D, Düzel E, Heinz A, Meyer-Lindenberg A, Seidenbecher C I, Walter H

Abstract excerpt

Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. Previous neuroimaging studies of depression-related endophenotypes have highlighted the role of the subgenual...

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Share to Calcium Channels, L-Type
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Identifiers

PMID: 24643163
DOI: 10.1038/tp.2014.10
PMCID: PMC3966038

Genes

PCLO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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