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Article

Genetic variation in CACNA1C, a gene associated with bipolar disorder, influences brainstem rather than gray matter volume in healthy individuals.

Biological psychiatry - 15 Sept 2010

Franke Barbara, Vasquez Alejandro Arias, Veltman Joris A, Brunner Han G, Rijpkema Mark, Fernández Guillén

Abstract excerpt

BACKGROUND: Genetic variation in CACNA1C has been repeatedly shown to increase risk for psychiatric disorders, with the strongest evidence for involvement in bipolar disorder. To elucidate the mechanisms by which such effects on psychiatric disease are brought about by genetic factors, we investigated the influence of CACNA1C polymorphisms on brain structure. METHODS: In 585 healthy volunteers, for whom magnetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20638048
DOI: 10.1016/j.biopsych.2010.05.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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