Association of rs1006737 in CACNA1C with alterations in prefrontal activation and fronto-hippocampal connectivity.

doi:10.1002/hbm.22244

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Article

Association of rs1006737 in CACNA1C with alterations in prefrontal activation and fronto-hippocampal connectivity.

Human brain mapping - 1 Apr 2014

Paulus Frieder M, Bedenbender Johannes, Krach Sören, Pyka Martin, Krug Axel, Sommer Jens, Mette Miriam, Nöthen Markus M, Witt Stephanie H, Rietschel Marcella, Kircher Tilo, Jansen Andreas

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified the rs1006737 single nucleotide polymorphism (SNP) in the CACNA1C gene as a susceptibility locus for schizophrenia and bipolar disorder. On the neural systems level this association is explained by altered functioning of the dorsolateral prefrontal cortex (DLPFC) and the hippocampal formation (HF), brain regions also affected by mental illness. In the...

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PMID: 23404764
DOI: 10.1002/hbm.22244
PMCID: PMC6869796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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