Article
Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014
Javid Babak, Sorrentino Flavia, Toosky Melody, Zheng Wen, Pinkham Jessica T, Jain Nina, Pan Miaomiao, Deighan Padraig, Rubin Eric J
Abstract excerpt
Errors are inherent in all biological systems. Errors in protein translation are particularly frequent giving rise to a collection of protein quasi-species, the diversity of which will vary according to the error rate. As mistranslation rates rise, these new proteins could produce new phenotypes, although none have been identified to date. Here, we find that mycobacteria substitute glutamate for glutamine and...
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