Article
Naturally occurring aminoacyl-tRNA synthetases editing-domain mutations that cause mistranslation in Mycoplasma parasites.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2011
Li Li, Boniecki Michal T, Jaffe Jacob D, Imai Brian S, Yau Peter M, Luthey-Schulten Zaida A, Martinis Susan A
Abstract excerpt
Mycoplasma parasites escape host immune responses via mechanisms that depend on remarkable phenotypic plasticity. Identification of these mechanisms is of great current interest. The aminoacyl-tRNA synthetases (AARSs) attach amino acids to their cognate tRNAs, but occasionally make errors that substitute closely similar amino acids. AARS editing pathways clear errors to avoid mistranslation during protein...
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