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Article

Long PCR-based genotyping for a deleted CYP2D6 gene without DNA extraction.

Drug metabolism and pharmacokinetics - 1 Jan 2014

Ota Tomoko, Hayashida Mariko, Ishii Minori, Iwao-Koizumi Kyoko, Murata Shigenori, Kinoshita Kenji

Abstract excerpt

In the post-genome era, a simple and inexpensive method for diagnostic analysis is in high demand. Cytochrome P450 (CYP) 2D6 is one of the most widely investigated CYPs in relation to genetic polymorphism. Detection of CYP2D6*5 is difficult since long PCR is used. Especially for samples without DNA extraction, the detection is not sensitive enough for population analysis. Therefore, we developed a CYP2D6*5...

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PMID: 24390472
DOI: 10.2133/dmpk.dmpk-13-nt-116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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