Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Optimized strategy for rapid cytochrome P450 2D6 genotyping by real-time long PCR.

Clinical chemistry - 1 Oct 2003

Müller Burkhardt, Zöpf Konstanze, Bachofer Julia, Steimer Werner

Abstract excerpt

BACKGROUND: Because of genetic polymorphisms, cytochrome P450 2D6 (Cyp2D6) activity in humans varies widely and alters the metabolism of commonly used drugs such as antidepressants, neuroleptics, and cardioactive agents. Severe adverse effects or resistance to therapy may result. METHODS: We performed long PCR on the LightCycler(TM) and used the product as a template for a previously validated multiplex PCR that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Primers
Share to Cytochrome P-450 CYP2D6
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Probes

Share to Fluorescent Dyes

Share to Gene Deletion

Share to Gene Duplication

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 14500587
DOI: 10.1373/49.10.1624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Optimized strategy for rapid cytochrome P450 2D6 genotyping by real-time long PCR.PMID 14500587Read ↗

Rapid detection of CYP2D6 null alleles by long distance- and multiplex-polymerase chain reaction.Semantic proximity Read ↗

Rapid and reliable method for cytochrome P450 2D6 genotyping.Semantic proximity Read ↗

Rapid detection of common cytochrome P450 2D6 alleles in Caucasians.Semantic proximity Read ↗

Long PCR-based genotyping for a deleted CYP2D6 gene without DNA extraction.Semantic proximity Read ↗

A rapid multiplex PCR assay that can reliably discriminate the cytochrome P450 2D6 whole-gene deletion allele from 2D6*10 alleles.Semantic proximity Read ↗

Pharmacogenetic screening of the gene deletion and duplications of CYP2D6.Semantic proximity Read ↗

Characterization of variant alleles of cytochrome CYP2D6 in a Spanish population.Semantic proximity Read ↗

CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele.Semantic proximity Read ↗

Alternative reliable method for cytochrome P450 2D6 poor metabolizers genotyping.Semantic proximity Read ↗

Rapid detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 alleles by tetra-primer PCR and of the CYP2D6*5 allele by multiplex long PCR.Semantic proximity Read ↗

Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology.Semantic proximity Read ↗

Long-Read Single Molecule Real-Time Full Gene Sequencing of Cytochrome P450-2D6.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.