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Article

Novel structure of the CYP2D6 gene that confuses genotyping for the CYP2D6*5 allele.

Drug metabolism and pharmacokinetics - 1 Oct 2005

Fukuda Tsuyoshi, Maune Hiromi, Ikenaga Yuka, Naohara Masakazu, Fukuda Kazuhiro, Azuma Junichi

Abstract excerpt

We encountered DNA samples which showed a positive product using a long PCR-based method for the detection of CYP2D6*5, indicating deletion of the entire CYP2D6 gene, but the samples did not show a band related to CYP2D6*5 in either XbaI- or EcoRI-RFLP analysis. To achieve genotyping with accuracy, we performed a further genetic analysis to clarify the discrepancy. An unknown 1.6-kb insert was identified in a...

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Identifiers

PMID: 16272752
DOI: 10.2133/dmpk.20.345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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