Article
Simultaneous genotyping of CYP2D6*3, *4, *5 and *6 polymorphisms in a Spanish population through multiplex long polymerase chain reaction and minisequencing multiplex single base extension analysis.
Clinical and experimental pharmacology & physiology - 1 Oct 2007
Crescenti A, Mas S, Gassó P, Baiget M, Bernardo M, Lafuente A
Abstract excerpt
1. The aim of the present study was to perform a descriptive study of the prevalence of the four major CYP2D6 poor metaboliser (PM) alleles (*3, *4, *5 and *6) in a Spanish population (n = 290) using a method based on a new combination of multiplex long polymerase chain reaction (PCR) and minisequencing through multiplex single base extension (SBE) analysis. 2. The method was validated using different strategies,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.