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Article

Genotyping CYP2D6 by three different methods: advantages and disadvantages.

Drug metabolism and personalized therapy - 1 Mar 2017

Ribeiro Carolina, Martins Patrícia, Grazina Manuela

Abstract excerpt

BACKGROUND: CYP2D6 belongs to P450 superfamily, and is responsible for the metabolism of 25% of the drugs used clinically. Genetic variability of CYP2D6 affects individual drug or toxic response leading to differences in the drug outcome or toxicity mediating adverse drug effects. The different variant alleles are associated with increased, decreased, or abolished enzyme hydroxylation functions. The CYP2D6*10...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28170339
DOI: 10.1515/dmpt-2016-0035

Variants

rs1065852

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