Article
Pharmacogenetic screening of the gene deletion and duplications of CYP2D6.
Drug metabolism reviews - 1 Jan 2007
Meijerman Irma, Sanderson Linda M, Smits Paul H M, Beijnen Jos H, Schellens Jan H M
Abstract excerpt
Cytochrome P450 (CYP) 2D6 is one of the most important enzymes involved in the metabolism of drugs. Multiple, clinically relevant, genetic variants of this gene have been identified and, among them, a gene deletion as well as multiplications of the gene. These large structural mutations in CYP2D6 occur at a relatively high frequency in several populations. Genotyping of CYP2D6 could therefore be applied to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.