Article
A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.
PloS one - 1 Jan 2013
Brummett Beverly H, Babyak Michael A, Jiang Rong, Shah Svati H, Becker Richard C, Haynes Carol, Chryst-Ladd Megan, Craig Damian M, Hauser Elizabeth R, Siegler Ilene C, Kuhn Cynthia M, Singh Abanish, Williams Redford B
Abstract excerpt
Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (rs6318) of the 5HTR2C gene located on the X-chromosome is associated with hypothalamic-pituitary-adrenal axis response to a stress recall task, and with endophenotypes associated with cardiovascular disease (CVD). These findings suggest that individuals carrying the rs6318 Ser23 C allele will be at higher risk for CVD...
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