Article
Alpha2A adrenergic receptor genetic variation contributes to hyperglycemia after myocardial infarction.
International journal of cardiology - 15 Jul 2016
Adefurin Abiodun, Vanderbilt Charles, Okafor Chimalum, Kawai Vivian, Li Chun, Shah Anushi, Wei Wei-Qi, Kurnik Daniel, Stein C Michael
Abstract excerpt
BACKGROUND: Acute myocardial infarction (AMI) is frequently associated with transient hyperglycemia even in patients without pre-existing diabetes. Acute stress can lead to increased blood glucose through the effect of catecholamines on alpha2A-adrenergic receptors (α2A-ARs) present in pancreatic islet β-cells. Variation in the gene (ADRA2A) that encodes the α2A-AR affects insulin release and glucose control and...
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