Article
Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly.
Circulation - 22 Apr 2003
Heckbert Susan R, Hindorff Lucia A, Edwards Karen L, Psaty Bruce M, Lumley Thomas, Siscovick David S, Tang Zhonghua, Durda J Peter, Kronmal Richard A, Tracy Russell P
Abstract excerpt
BACKGROUND: Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study. METHODS AND RESULTS: A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms...
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