Article
Beta2-adrenergic receptor genetic variants and risk of sudden cardiac death.
Circulation - 18 Apr 2006
Sotoodehnia Nona, Siscovick David S, Vatta Matteo, Psaty Bruce M, Tracy Russell P, Towbin Jeffrey A, Lemaitre Rozenn N, Rea Thomas D, Durda J Peter, Chang Joel M, Lumley Thomas S, Kuller Lewis H, Burke Gregory L, Heckbert Susan R
Abstract excerpt
BACKGROUND: Sympathetic activation influences the risk of ventricular arrhythmias and sudden cardiac death (SCD), mediated in part by the beta2-adrenergic receptor (B2AR). We investigated whether variation in the B2AR gene is associated with SCD risk. METHODS AND RESULTS: In this study, 4441 white and 808 black Cardiovascular Health Study (CHS) participants were followed up prospectively for SCD and genotyped for...
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