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Article

A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.

PloS one - 1 Jan 2014

Brummett Beverly H, Babyak Michael A, Williams Redford B, Harris Kathleen Mullan, Jiang Rong, Kraus William E, Singh Abanish, Costa Paul T, Georgiades Anastasia, Siegler Ilene C

Abstract excerpt

Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive symptoms, although the precise causal pathway remains unclear. Activity of the x-linked serotonin 5-HTR2C receptor has also been shown to be associated with depression and with clinical response...

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Source

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Identifiers

PMID: 25514629
DOI: 10.1371/journal.pone.0114451
PMCID: PMC4267787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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