Article
Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts.
Aging cell - 1 Feb 2010
Nooteboom Marco, Johnson Riem, Taylor Robert W, Wright Nicholas A, Lightowlers Robert N, Kirkwood Thomas B L, Mathers John C, Turnbull Doug M, Greaves Laura C
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations are a cause of human disease and are proposed to have a role in human aging. Clonally expanded mtDNA point mutations have been detected in replicating tissues and have been shown to cause respiratory chain (RC) defects. The effect of these mutations on other cellular functions has not been established. Here, we investigate the consequences of RC deficiency on human colonic...
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