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Article

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.

Cell stem cell - 4 Jun 2015

Adams Peter D, Jasper Heinrich, Rudolph K Lenhard

Abstract excerpt

Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem and progenitor cell populations in aging tissues, such as the intestinal epithelium, the hematopoietic system, and the male germline. Here we discuss possible explanations for age-associated increases in the initiation and/or...

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Identifiers

PMID: 26046760
DOI: 10.1016/j.stem.2015.05.002
PMCID: PMC4509784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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