Article
Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations.
The Journal of pathology - 1 Dec 2018
Su Tianhong, Grady John P, Afshar Sorena, McDonald Stuart Ac, Taylor Robert W, Turnbull Doug M, Greaves Laura C
Abstract excerpt
Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations decreases over time in blood, suggesting selection against the mutation. However, it is unknown whether such selection occurs in other mitotic tissues, and where it occurs within the tissue....
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