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Germline CDH1 mutations in bilateral lobular carcinoma in situ

24 Dec 2013

Abstract excerpt

BACKGROUND: Invasive lobular breast cancer (ILC) and lobular carcinoma in situ (LCIS) are characterised by loss of E-cadherin expression. However germline CDH1 mutations are rare in cases of ILC with no family history of hereditary diffuse gastric cancer (HDGC) and have not been described in women with LCIS. METHODS: We screened the CDH1 gene in 50 cases of bilateral LCIS/ILC using Sanger sequencing and MLPA....

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PMID: 24366306
DOI: 10.1038/bjc.2013.792

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