CDH1 Genotype Exploration in Women With Hereditary Lobular Breast Cancer Phenotype.

doi:10.1001/jamanetworkopen.2024.7862

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Article

CDH1 Genotype Exploration in Women With Hereditary Lobular Breast Cancer Phenotype.

JAMA network open - 1 Apr 2024

Corso Giovanni, Marino Elena, Zanzottera Cristina, Oliveira Carla, Bernard Loris, Macis Debora, Figueiredo Joana, Pereira Joana, Carneiro Patrícia, Massari Giulia, Barberis Massimo, De Scalzi Alessandra Margherita, Taormina Sergio Vincenzo, Sajjadi Elham, Sangalli Claudia, Gandini Sara, D'Ecclesiis Oriana, Trovato Cristina Maria, Rotili Anna, Pesapane Filippo, Nicosia Luca, La Vecchia Carlo, Galimberti Viviana, Guerini-Rocco Elena, Bonanni Bernardo, Veronesi Paolo

Abstract excerpt

Importance: Pathogenic or likely pathogenic (P/LP) germline CDH1 variants are associated with risk for diffuse gastric cancer and lobular breast cancer (LBC) in the so-called hereditary diffuse gastric cancer (HDGC) syndrome. However, in some circumstances, LBC can be the first manifestation of this syndrome in the absence of diffuse gastric cancer manifestation. Objectives: To evaluate the frequency of germline...

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PMID: 38652475
DOI: 10.1001/jamanetworkopen.2024.7862
PMCID: PMC11040411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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