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Article

CDH1 mutation screen in a BRCA1/2-negative familial breast-/ovarian cancer cohort.

Archives of gynecology and obstetrics - 1 Jan 2018

Stuebs Frederik, Heidemann Simone, Caliebe Almuth, Mundhenke Christoph, Arnold Norbert

Abstract excerpt

PURPOSE: Mutations in the CDH1 gene are linked both to diffuse gastric cancer and invasive lobular carcinoma (ILC). A high mutation rate is found in families fulfilling the diagnostic criteria for hereditary diffuse gastric cancer. Aim of this study was to clarify whether or not there is a significant contribution of CDH1 mutations in hereditary breast-/ovarian cancer (HBOC). METHODS: Ninety-seven unrelated...

Topics

Adult
Antigens, CD
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Cadherins
Cohort Studies
Early Detection of Cancer
Female
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Ovarian Neoplasms

Source

Identifiers

PMID: 28993866
DOI: 10.1007/s00404-017-4551-1

Genes

CDH1
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-28993866-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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