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Article

Unexpected CDH1 Mutations Identified on Multigene Panels Pose Clinical Management Challenges

7 Jul 2017

Abstract excerpt

Purpose Mutations in the CDH1 gene confer up to an 80% lifetime risk of diffuse gastric cancer and up to a 60% lifetime risk of lobular breast cancer. Testing for CDH1 mutations is recommended for individuals who meet the International Gastric Cancer Linkage Consortium (IGCLC) guidelines. However, the interpretation of unexpected CDH1 mutations identified in patients who do not meet IGCLC criteria or do not have...

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Identifiers

PMID: 35172483
DOI: 10.1200/po.16.00021

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