Article
CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study.
Journal of medical genetics - 1 Jul 2013
Benusiglio Patrick R, Malka David, Rouleau Etienne, De Pauw Antoine, Buecher Bruno, Noguès Catherine, Fourme Emmanuelle, Colas Chrystelle, Coulet Florence, Warcoin Mathilde, Grandjouan Sophie, Sezeur Alain, Laurent-Puig Pierre, Molière Diane, Tlemsani Camille, Di Maria Marina, Byrde Veronique, Delaloge Suzette, Blayau Martine, Caron Olivier
Abstract excerpt
INTRODUCTION: CDH1 predisposes primarily to diffuse gastric cancer (DGC). Multiple DGC cases in a family, DGC at a young age in an individual or the combination of DGC andlobular breast cancer (LBC) in an individual or a family define the hereditary DGC syndrome (HDGC), and testing for germline CDH1 mutations is warranted in HDGC. METHODS AND RESULTS: We report all index cases from Ile-de-France in which a...
Topics
- Adult
- Antigens, CD
- Breast Neoplasms
- Cadherins
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans