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Article

CDH1 germline mutations in families with hereditary lobular breast cancer.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 May 2022

Girardi Antonia, Magnoni Francesca, Vicini Elisa, Kouloura Andriana, La Vecchia Carlo, Veronesi Paolo, Corso Giovanni

Abstract excerpt

Pathogenic CDH1 germline mutations are associated with lobular breast cancer in the so-called hereditary lobular breast cancer (HLBC) syndrome, without apparent correlation with the classic hereditary diffuse gastric cancer (HDGC). Recent international guidelines recommend CDH1 screening also in absence of diffuse gastric cancer (DGC) history. Genomic characteristics underlying gastric and breast tumorigenesis in...

Topics

Antigens, CD
Breast Neoplasms
Cadherins
Carcinoma, Lobular
Female
Genetic Predisposition to Disease
Germ-Line Mutation
Heterozygote
Humans
Stomach Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33990097
DOI: 10.1097/CEJ.0000000000000688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-33990097-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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