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Article

Bilateral Prophylactic and Contralateral Risk-Reducing Mastectomy in Women With Germline CDH1 Pathogenic or Likely-Pathogenic Variants.

Journal of surgical oncology - 1 Sept 2026

Corso Giovanni, Vecchia Carlo La, Magnoni Francesca, Polizzi Andrea, Bottazzoli Elisa, Scalzi Alessandra De, Silvestre Susanna Di, Meduri Eleonora, Pesapane Filippo, Nicosia Luca, Lorenzi Francesca De, Intra Mattia, Galimberti Viviana, Veronesi Paolo

Abstract excerpt

Bilateral prophylactic mastectomy (BPM) or contralateral risk-reducing mastectomy (CRRM) are considered in CDH1 carriers as a strategy to reduce lobular breast cancer (LBC) risk in women. In this study we aimed to evaluate the overall number of these procedures reported in literature. We conducted a literature search and a scoping review through the PUBMED database. We identified eleven studies eligible for our...

Read the complete abstract on PubMed

Topics

Humans
Female
Cadherins
Prophylactic Mastectomy
Antigens, CD

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Breast Neoplasms

Germ-Line Mutation

Genetic Predisposition to Disease

Carcinoma, Lobular

Source

Open in PubMed Open full text

Identifiers

PMID: 42437507
DOI: 10.1002/jso.70323
PMCID: PMC13575603

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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