Article
E-cadherin germline mutation carriers: clinical management and genetic implications.
Cancer metastasis reviews - 1 Dec 2014
Corso Giovanni, Figueiredo Joana, Biffi Roberto, Trentin Chiara, Bonanni Bernardo, Feroce Irene, Serrano Davide, Cassano Enrico, Annibale Bruno, Melo Soraia, Seruca Raquel, De Lorenzi Francesca, Ferrara Francesco, Piagnerelli Riccardo, Roviello Franco, Galimberti Viviana
Abstract excerpt
Hereditary diffuse gastric cancer is an autosomic dominant syndrome associated with E-cadherin protein (CDH1) gene germline mutations. Clinical criteria for genetic screening were revised in 2010 by the International Gastric Cancer Linkage Consortium at the Cambridge meeting. About 40 % of families fulfilling clinical criteria for this inherited disease present deleterious CDH1 germline mutations. Lobular breast...
Topics
- Breast Neoplasms
- Cadherins
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Genetic Therapy
- Germ-Line Mutation
- Heterozygote
- Humans
- Stomach Neoplasms