Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect.

doi:10.1136/jmedgenet-2018-105337

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Article

Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect.

Journal of medical genetics - 1 Jul 2018

Corso Giovanni, Figueiredo Joana, La Vecchia Carlo, Veronesi Paolo, Pravettoni Gabriella, Macis Debora, Karam Rachid, Lo Gullo Roberto, Provenzano Elena, Toesca Antonio, Mazzocco Ketti, Carneiro Fátima, Seruca Raquel, Melo Soraia, Schmitt Fernando, Roviello Franco, De Scalzi Alessandra Margherita, Intra Mattia, Feroce Irene, De Camilli Elisa, Villardita Maria Grazia, Trentin Chiara, De Lorenzi Francesca, Bonanni Bernardo, Galimberti Viviana

Abstract excerpt

Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer (LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A multidisciplinary workgroup discussed genetic susceptibility, pathophysiology and clinical management of hereditary LBC (HLBC). The team has established the clinical criteria for CDH1 screening and results' interpretation, and created...

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PMID: 29929997
DOI: 10.1136/jmedgenet-2018-105337

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CDH1

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