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Article

CDH1 germline mutations and hereditary lobular breast cancer.

Familial cancer - 1 Apr 2016

Corso Giovanni, Intra Mattia, Trentin Chiara, Veronesi Paolo, Galimberti Viviana

Abstract excerpt

Hereditary diffuse gastric cancer is an autosomal dominant inherited disease associated of CDH1 germline mutations (that encodes for the E-cadherin protein), and lobular breast cancer is the second most frequent type of neoplasia. Recently, novel E-cadherin constitutional alterations have been identified in pedigree clustering only for lobular breast carcinoma without evidence of diffuse gastric tumors and in...

Topics

Antigens, CD
Breast Neoplasms
Cadherins
Carcinoma, Lobular
Female
Genetic Predisposition to Disease
Genetic Testing
Germ-Line Mutation
Heterozygote
Humans
Mutation Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26759166
DOI: 10.1007/s10689-016-9869-5

Genes

CDH1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26759166-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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