Article
Type 2 deiodinase Thr92Ala polymorphism is associated with disrupted placental activity but not with dysglycemia or adverse gestational outcomes: a genetic association study.
Fertility and sterility - 1 Mar 2014
Dora José Miguel, Wajner Simone M, Costa Juliano Dalla, Pinto Ribeiro Rafaela Vanin, Leiria Leonardo Barbosa, Lopes Mariah G, Vitali da Silva Aline, Crispim Daisy, Maia Ana Luiza
Abstract excerpt
OBJECTIVE: To study whether the D2 Thr92Ala polymorphism-a genetic marker that is associated with reduced thyroid type 2 deiodinase (D2) activity, increased insulin resistance, and risk for type 2 diabetes-is associated with disrupted placental D2 activity and with glycemic control and gestational outcomes. DESIGN: Cross-sectional study. SETTING: Tertiary hospital in Brazil. PATIENT(S): Consecutive...
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