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Article

Association Between a Novel Variant of the Human Type 2 Deiodinase Gene Thr92Ala and Insulin Resistance

1 Mar 2002

Abstract excerpt

Thyroid hormone action is an important determinant of energy and glucose metabolism. T4 metabolism is regulated by the deiodinases of which type 2 is expressed in humans in skeletal muscle and brown adipose tissue, where its transcription is stimulated by the beta-3 adrenergic pathway. We performed molecular scanning of the human type 2 deiodinase (DIO2) gene and evaluated a novel variant for associations with...

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PMID: 11872697
DOI: 10.2337/diabetes.51.3.880

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Association Between a Novel Variant of the Human Type 2 Deiodinase Gene Thr92Ala and Insulin ResistancePMID 11872697Read ↗

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Type 2 deiodinase Thr92Ala polymorphism is associated with a reduction in bone mineral density: A community-based korean genome and epidemiology study.Semantic proximity Read ↗

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The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.Semantic proximity Read ↗

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