Article
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism - 1 Jun 2005
Canani Luis Henrique, Capp Clarissa, Dora José Miguel, Meyer Erika L Souza, Wagner Márcia S, Harney John W, Larsen P Reed, Gross Jorge L, Bianco Antonio C, Maia Ana Luiza
Abstract excerpt
The single-nucleotide polymorphism A/G in the type 2 deiodinase (D2) gene predicts a threonine (Thr) to alanine (Ala) substitution at codon 92 (D2 Thr92Ala) and is associated with insulin resistance in obese patients. Here, this association was investigated in 183 patients with type 2 diabetes mellitus, using homeostasis model assessment. The median fasting plasma insulin in Ala/Ala individuals was significantly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.