Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis.

European journal of endocrinology - 1 Sept 2010

Dora José Miguel, Machado Walter Escouto, Rheinheimer Jakeline, Crispim Daisy, Maia Ana Luiza

Abstract excerpt

OBJECTIVE: The type 2 deiodinase (D2) is a key enzyme for intracellular triiodothyronine (T(3)) generation. A single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects. Our aim was to evaluate whether the D2 Thr92Ala polymorphism is associated with increased risk for DM2. DESIGN AND METHODS: A case-control study with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Iodide Peroxidase

Share to Iodothyronine Deiodinase Type II

Share to Multicenter Studies as Topic

Share to Single-Blind Method

Share to Threonine

Source

Identifiers

PMID: 20566590
DOI: 10.1530/EJE-10-0419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis.PMID 20566590Read ↗

The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Higher Body Mass Index and Fasting Glucose Levels: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Association Between a Novel Variant of the Human Type 2 Deiodinase Gene Thr92Ala and Insulin ResistanceSemantic proximity Read ↗

The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.Semantic proximity Read ↗

Type 2 deiodinase Thr92Ala polymorphism is associated with disrupted placental activity but not with dysglycemia or adverse gestational outcomes: a genetic association study.Semantic proximity Read ↗

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects.Semantic proximity Read ↗

The Physiological Functions and Polymorphisms of Type II DeiodinaseSemantic proximity Read ↗

The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance.Semantic proximity Read ↗

Thr92Ala polymorphism of human type 2 deiodinase gene (hD2) affects the development of Graves' disease, treatment efficiency, and rate of remission.Semantic proximity Read ↗

Type 2 deiodinase p.Thr92Ala polymorphism does not affect the severity of obesity and weight loss after bariatric surgery.Semantic proximity Read ↗

Type 2 Deiodinase p.Thr92Ala polymorphism does not affect the severity of obesity and weight loss after bariatric surgerySemantic proximity Read ↗

D2 Thr92Ala and PPARγ2 Pro12Ala polymorphisms interact in the modulation of insulin resistance in type 2 diabetic patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.