The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance.

doi:10.1371/journal.pone.0103960

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Article

The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance.

PloS one - 1 Jan 2014

Leiria Leonardo B, Dora José M, Wajner Simone M, Estivalet Aline A F, Crispim Daisy, Maia Ana Luiza

Abstract excerpt

The Thr92Ala (rs225014) polymorphism in the type 2 deiodinase (DIO2) gene has been associated with insulin resistance (IR) and decreased enzyme activity in human tissues but kinetic studies failed to detect changes in the mutant enzyme, suggesting that this variant might be a marker of abnormal DIO2 expression. Thus, we aimed to investigate whether other DIO2 polymorphisms, individually or in combination with the...

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Identifiers

PMID: 25105294
DOI: 10.1371/journal.pone.0103960
PMCID: PMC4126657

Genes

DIO2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance.PMID 25105294Read ↗

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