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Article

Differential inhibition of LINE1 and LINE2 retrotransposition by vertebrate AID/APOBEC proteins

1 Dec 2013

Abstract excerpt

BACKGROUND: The role of AID/APOBEC proteins in the mammalian immune response against retroviruses and retrotransposons is well established. G to A hypermutations, the hallmark of their cytidine deaminase activity, are present in several mammalian retrotransposons. However, the role of AID/APOBEC proteins in non-mammalian retroelement restriction is not completely understood. RESULTS: Here we provide the first...

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PMID: 24344916
DOI: 10.1186/1742-4690-10-156

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