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Article

LINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase.

PloS one - 1 Jan 2012

Metzner Mirjam, Jäck Hans-Martin, Wabl Matthias

Abstract excerpt

LINE-1 (abbreviated L1) is a major class of retroelements in humans and mice. If unrestricted, retroelements accumulate in the cytoplasm and insert their DNA into the host genome, with the potential to cause autoimmune disease and cancer. Retroviruses and other retroelements are inhibited by proteins of the APOBEC family, of which activation-induced cytidine deaminase (AID) is a member. Although AID is mainly...

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Identifiers

PMID: 23133680
DOI: 10.1371/journal.pone.0049358
PMCID: PMC3487726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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