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Article

RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition

29 Jun 2018

Abstract excerpt

Long INterspersed Element class 1 (LINE‐1) elements are a type of abundant retrotransposons active in mammalian genomes. An average human genome contains ~100 retrotransposition‐competent LINE‐1s, whose activity is influenced by the combined action of cellular repressors and activators. TREX1, SAMHD1 and ADAR1 are known LINE‐1 repressors and when mutated cause the autoinflammatory disorder Aicardi‐Goutières...

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PMID: 29959219
DOI: 10.15252/embj.201798506

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