Article
A Long-Running Arms Race between APOBEC1 Genes and Retroviruses in Tetrapods.
Journal of virology - 31 Jan 2023
Wang Wenqiang, Han Guan-Zhu
Abstract excerpt
Activation-induced cytidine deaminase/apolipoprotein B mRNA editing catalytic polypeptide-like (AID/APOBEC) proteins are cytosine deaminases implicated in diverse biological functions. APOBEC1 (A1) proteins have long been thought to regulate lipid metabolism, whereas the evolutionary significance of A1 proteins in antiviral defense remains largely obscure. Endogenous retroviruses (ERVs) document past retroviral...
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