Article
Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 2006
Bogerd Hal P, Wiegand Heather L, Hulme Amy E, Garcia-Perez José L, O'Shea K Sue, Moran John V, Cullen Bryan R
Abstract excerpt
Long interspersed element (LINE) 1 retrotransposons are major genomic parasites that represent approximately 17% of the human genome. The LINE-1 ORF2 protein is also responsible for the mobility of Alu elements, which constitute a further approximately 11% of genomic DNA. Representative members of each element class remain mobile, and deleterious retrotransposition events can induce spontaneous genetic diseases....
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