Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Creative deaminases, self-inflicted damage, and genome evolution.

Annals of the New York Academy of Sciences - 1 Sept 2012

Conticello Silvestro G

Abstract excerpt

Organisms minimize genetic damage through complex pathways of DNA repair. Yet a gene family--the AID/APOBECs--has evolved in vertebrates with the sole purpose of producing targeted damage in DNA/RNA molecules through cytosine deamination. They likely originated from deaminases involved in A>I editing in tRNAs. AID, the archetypal AID/APOBEC, is the trigger of the somatic diversification processes of the antibody...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to Evolution, Molecular
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulins

Share to Mutagenesis

Share to Neoplasms

Share to RNA Editing

Source

Identifiers

PMID: 22954220
DOI: 10.1111/j.1749-6632.2012.06614.x

Genes

APOBEC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Creative deaminases, self-inflicted damage, and genome evolution.PMID 22954220Read ↗

Aid and Apobec Deaminases: Balancing Dna Damage in Epigenetics and ImmunitySemantic proximity Read ↗

DNA deamination in immunitySemantic proximity Read ↗

The mutagenic source and power of our own evolution.Semantic proximity Read ↗

Functions and Malfunctions of Mammalian DNA-Cytosine DeaminasesSemantic proximity Read ↗

The AID/APOBEC family of nucleic acid mutatorsSemantic proximity Read ↗

Reward versus Risk: DNA Cytidine Deaminases Triggering Immunity and DiseaseSemantic proximity Read ↗

Generation of Genomic Alteration from Cytidine Deamination.Semantic proximity Read ↗

AID-initiated purposeful mutations in immunoglobulin genes.Semantic proximity Read ↗

AID Biology: A pathological and clinical perspectiveSemantic proximity Read ↗

Evolution of the AID/APOBEC Family of Polynucleotide (Deoxy)cytidine DeaminasesSemantic proximity Read ↗

APOBEC3 family proteins as drivers of virus evolutionSemantic proximity Read ↗

Activation induced cytidine deaminase: An old friend with new facesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.