Article
Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins.
Nucleic acids research - 1 Jan 2006
Jónsson Stefán R, Haché Guylaine, Stenglein Mark D, Fahrenkrug Scott C, Andrésdóttir Valgerdur, Harris Reuben S
Abstract excerpt
The APOBEC3 proteins are unique to mammals. Many inhibit retrovirus infection through a cDNA cytosine deamination mechanism. HIV-1 neutralizes this host defense through Vif, which triggers APOBEC3 ubiquitination and degradation. Here, we report an APOBEC3F-like, double deaminase domain protein from three artiodactyls: cattle, pigs and sheep. Like their human counterparts, APOBEC3F and APOBEC3G, the artiodactyl...
Topics
- Amino Acid Sequence
- Animals
- Artiodactyla
- Catalysis
- Cattle
- Cytoplasm
- Cytosine Deaminase
- Deamination
- Evolution, Molecular
- Gene Products, vif
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation