Article
AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity.
Nucleic acids research - 1 Apr 2009
MacDuff Donna A, Demorest Zachary L, Harris Reuben S
Abstract excerpt
Retrotransposons make up over 40% of the mammalian genome. Some copies are still capable of mobilizing and new insertions promote genetic variation. Several members of the APOBEC3 family of DNA cytosine deaminases function to limit the replication of a variety of retroelements, such as the long-terminal repeat (LTR)-containing MusD and Ty1 elements, and that of the non-LTR retrotransposons, L1 and Alu. However,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.