Article
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific.
Aging cell - 1 Jun 2014
Raule Nicola, Sevini Federica, Li Shengting, Barbieri Annalaura, Tallaro Federica, Lomartire Laura, Vianello Dario, Montesanto Alberto, Moilanen Jukka S, Bezrukov Vladyslav, Blanché Hélène, Hervonen Antti, Christensen Kaare, Deiana Luca, Gonos Efstathios S, Kirkwood Tom B L, Kristensen Peter, Leon Alberta, Pelicci Pier Giuseppe, Poulain Michel, Rea Irene M, Remacle Josè, Robine Jean Marie, Schreiber Stefan, Sikora Ewa, Eline Slagboom Peternella, Spazzafumo Liana, Antonietta Stazi Maria, Toussaint Olivier, Vaupel James W, Rose Giuseppina, Majamaa Kari, Perola Markus, Johnson Thomas E, Bolund Lars, Yang Huanming, Passarino Giuseppe, Franceschi Claudio
Abstract excerpt
To re-examine the correlation between mtDNA variability and longevity, we examined mtDNAs from samples obtained from over 2200 ultranonagenarians (and an equal number of controls) collected within the framework of the GEHA EU project. The samples were categorized by high-resolution classification, while about 1300 mtDNA molecules (650 ultranonagenarians and an equal number of controls) were completely sequenced....
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