Article
Mitochondrial DNA involvement in human longevity.
Biochimica et biophysica acta - 1 Jan 2000
Santoro Aurelia, Salvioli Stefano, Raule Nicola, Capri Miriam, Sevini Federica, Valensin Silvana, Monti Daniela, Bellizzi Dina, Passarino Giuseppe, Rose Giuseppina, De Benedictis Giovanna, Franceschi Claudio
Abstract excerpt
The main message of this review can be summarized as follows: aging and longevity, as complex traits having a significant genetic component, likely depend on a number of nuclear gene variants interacting with mtDNA variability both inherited and somatic. We reviewed the data available in the literature with particular attention to human longevity, and argued that what we hypothesize for aging and longevity could...
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