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Article

Role of mitochondrial DNA in longevity, aging and age-related diseases in humans: a reappraisal.

The Italian journal of biochemistry - 1 Dec 2007

Sevini Federica, Santoro Aurelia, Raule Nicola, Lescai Francesco, Franceschi Claudio

Abstract excerpt

The genetic variability of H. sapiens mitochondrial DNA (mtDNA) can be either germ-line inherited or somatically acquired, and its effect on aging and longevity as well as on the pathogenesis of complex age-related diseases is a hot topic. Here we illustrate the complexity of such studies, related to the large genetic variability of mtDNA in different populations and the fact that the rate of the aging process is...

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PMID: 19192621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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